Cancer IO Sebinar: Single-cell tumor immunity

Welcome to the Cancer IO Sebinar Session III: ‘Single-cell tumor immunity’ on 16th of September 2021, 15:00-16:45 EEST!

This is the third session of the bi-monthly Cancer IO sebinar (webinar + seminar) series. Welcome to join the event in Zoom. The event is open to all inter­ested in this fas­cin­ating topic. More inform­ation below and in LinkedIn

Stu­dents can receive credits for this seminar, where 1 ETSF is given to stu­dents who attend 5 sebinars and hand in a ½ page layman’s abstracts for each of these. Instruc­tions will be provided at the start of each sebinar. Regis­tration is open on WebOodi.

This inter­active bi-monthly sebinar series aims to bring you the newest devel­op­ments in the field of immuno-oncology presented by leading sci­entists. Every sebinar will have an important inter­active element in the form of a panel dis­cussion, where the invited speaker dis­cusses a timely topic with local sci­entists and clini­cians. Sebinar attendants are wel­comed to par­ti­cipate in the dis­cussion using the Q&A feature. 

This time we will hear about the latest devel­op­ments in single-cell sequencing and spatial tran­scrip­tomics in regards of tumor immunity. In the panel dis­cussion, we address if and how these new tech­no­logies can be taken from basic research tools towards clinical dia­gnostics. Our invited speaker Bernd Boden­miller holds a dual pro­fess­orship with the Uni­versity of Zurich (Institute of Molecular Life Sci­ences and Department of Quant­it­ative Biomedicine).


15:00 - 15:10 Intro­duction:  Single-cell res­ol­ution to immune responses

MD PhD, Group Leader Anniina Färkkilä (Uni­versity of Hel­sinki, Finland)

15:10 - 15:20 Spatial solu­tions for single-cell omics 

CEO Päivi Saava­lainen (SCellex)

15:20 - 16:10 Pro­filing tumor immunity at single-cell level   

Prof. Bernd Boden­miller (Uni­versity of Zurich)

16:10 - 16:20 Q&A

16:20 – 16:45 Panel Dis­cussion: Single-cell pathology – Utopia or reality?

Pan­elists: Bernd Boden­miller, Anniina Färkkilä, Päivi Saava­lainen, Eevi Kaasinen (Uni­versity of Helsinki)

Session Chair: Heidi Haikala, Cancer IO 

Bio­graphy for Dr. Bernd Bodenmiller:

Pro­fessor Bernd Boden­miller was appointed Asso­ciate Pro­fessor of Quant­it­ative Bio­medicine in the Department of Biology. He holds a dual pro­fess­orship with the Uni­versity of Zurich. Bernd Boden­miller’s research invest­igates the mech­anisms of cancer eco­systems. His work iden­tified novel tumor and immune cell phen­o­types asso­ciated with clinical fea­tures, sig­naling mech­anisms leading to therapy res­istance, and exper­i­mental and com­pu­ta­tional methods to image tissues in a highly mul­ti­plexed manner in situ. These methods are widely used by researchers and also in clinical studies. Bernd Boden­miller has developed an excellent inter­na­tional network and has received several awards, including an ERC Starting Grant and an ERC Con­sol­idator Grant. In addition, he is the founding dir­ector of the Department of Quant­it­ative Bio­medicine at the Uni­versity of Zurich.

After his graduate studies in bio­chem­istry at ETH Zurich and a PhD in the lab of Ruedi Aebersold (2004 to 2008), he con­tinued his research with two postdoc­toral pos­i­tions in the Aebersold lab and the Nolan lab (Stanford). In 2013, he returned to Zurich where he obtained an SNSF assistant pro­fess­orship at the Institute of Molecular Life Sci­ences (Uni­versity of Zurich). Since 2019, Bernd Boden­miller is the dir­ector of the Department of Quant­it­ative Bio­medicine (UZH).

Selected pub­lic­a­tions:

Jackson HW, Fischer JR, Zan­o­telli VRT, Ali HR, Mechera R, Soysal SD, Moch H, Muenst S, Varga Z, Weber WP, Boden­miller B: The single-cell pathology land­scape of breast cancer. Nature 2020 Feb; 578(7796):615-620.

Wagner J, Rap­so­maniki MA, Chevrier S, Anzeneder T, Lang­wieder C, Dykgers A, Rees M, Ramaswamy A, Muenst S, Soysal SD, Jacobs A, Wind­hager J, Silina K, van den Broek M, Dedes KJ, Rodríguez Martínez M, Weber WP, Boden­miller B: A single-cell atlas of the tumor and immune eco­system of human breast cancer. Cell 2019 May 16;177(5):1330-1345.e18.

Damond N, Engler S, Zan­o­telli VRT, Schapiro D, Wasserfall CH, Kus­martseva I, Nick HS, Thorel F, Herrera PL, Atkinson MA, Boden­miller B: A map of human type I dia­betes pro­gression by imaging mass cyto­metry. Cell Meta­bolism 29(3): 755-768.E5

Chevrier S, Crowell HL, Zan­o­telli VRT, Engler S, Robinson MD, Boden­miller B: Com­pens­ation of signal spillover in sus­pension and imaging mass cyto­metry. Cell Systems 6(5), 612-620 (2018).

Schulz D, Zan­o­telli VRT, Fischer JR, Schapiro D, Engler S, Lun XK, Jackson, HW, Boden­miller B: Sim­ul­taneous mul­ti­plexed imaging of mRNA and pro­teins with sub­cel­lular res­ol­ution in breast cancer tissue samples by mass cyto­metry. Cell Systems 6(1), 25 - 36 (2018).

Schapiro D, Jackson HW, Raghuraman S, Fischer JR, Zan­o­telli VRT, Schulz D, Giesen C, Catena R, Varga Z, Boden­miller B: His­toCAT: ana­lysis of cell phen­o­types and inter­ac­tions in mul­tiplex image cyto­metry data. Nature Methods 14, 873–876 (2017).

Chevrier S, Levine JH, Zan­o­telli VRT, Silina K, Schulz D, Bacac M, Ries CH, Ailles L, Jewett MAS, Moch H, van den Broek M, Beisel C, Stadler MB, Gedye C, Reis B, Pe’er D, Boden­miller B: An immune atlas of clear cell renal cell car­cinom. Cell 169(4), 736 - 749 (2017).

Lun XK, Zan­o­telli VRT, Wade JW, Schapiro D, Tognetti M, Dob­ber­stein N, Boden­miller B: Influence of node abundance on sig­naling network state and dynamics ana­lyzed by mass cyto­metry. Nature Bio­tech­nology 35, 164–172 (2017).

Giesen C, Wang HAO, Schapiro D, Zivanovic N, Jacobs A, Hat­tendorf B, Schueffler PJ, Grolimund D, Buhmann JM, Brandt S, Varva Z, Wild PJ, Guenther D, Boden­miller B: Highly mul­ti­plexed imaging of tumor tissues with sub­cel­lular res­ol­ution by mass cyto­metry. Nature Methods 11, 417–422 (2014). 

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