Cancer IO Academic Research Groups
Cancer IO’s academic research is conducted in three laboratories: Klefström Lab and Translational Immunology Program located at the University of Helsinki, and Hollmén lab at the University of Turku.
Klefström Lab
Juha Klefström, Research Director, FICAN Research Professor
Translational Cancer Biology Research Program
Faculty of Medicine
University of Helsinki
Hollmén lab
Our research exploits a unique scavenger receptor Clever-1, expressed on a subpopulation of immunosuppressive macrophages, to alleviate tumor related inflammation and develop Clever-1 as a companion therapeutic, diagnostic, and prognostic biomarker to treat and identify patients under immunosuppression. This involves the use of in vivo tumor models and sophisticated immunological assays with cutting-edge technology and state-of-the-art imaging combined with fresh human cancer patient material to elucidate the function of Clever-1 in controlling macrophage mediated local and systemic immune responses. Our results potentially have a high impact in understanding the mechanism of macrophage-mediated immunosuppression in cancer and promoting anti-Clever-1 immunotherapy into clinical trials where it may have benefits in comparison with currently available immune activating drugs.
Medicity Research Laboratory
Institute of Biomedicine
University of Turku
Mustjoki Lab
Immunology is presently one of the most rapidly developing fields of medical science. Increasing understanding of the regulation of immune responses has led to the launch of several new therapeutic agents for clinical use especially in cancer. However, not all cancer patients are responding to current immunological treatments and no cure or prevention is available for autoimmune diseases. The ambitious goal of Translational Immunology Research Program (TRIMM) is to explore the development and regulation of T cells and immune tolerance and understand the aberrant immune responses in auto- and alloimmune diseases and cancer.
Satu Mustjoki, Program Director
Hematology Research Unit
University of Helsinki
Translational Immunology Program TRIMM website
